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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistanceaccordingly a key mechanism of drug acquired resistance in cancer therapy.to apoptosis is tightly associated with the emergence of acquired resistance.sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquiredresistance to third generation EGFR-TKIs.

Keywords： acquired resistance EGFR inhibitor apoptosis lung cancer

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lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: described the key features and prognostic roles of lung microbiota in patients with severe community-acquired

Keywords： severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale

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bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired

Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 718-727 doi: 10.1007/s11684-020-0807-4

Abstract: Severe aplastic anemia II (SAA-II) progresses from non-severe aplastic anemia (NSAA). The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation (haplo-BMT) in patients lacking a human leukocyte antigen (HLA)-matched donor. This study aimed to investigate the efficacy of haplo-BMT for patients with SAA-II. Twenty-two patients were included and followed up, and FLU/BU/CY/ATG was used as conditioning regimen. Among these patients, 21 were successfully engrafted, 19 of whom survived after haplo-BMT. Four patients experienced grade II–IV aGvHD, including two with grade III–IV aGvHD. Six patients experienced chronic GvHD, among whom four were mild and two were moderate. Twelve patients experienced infections during BMT. One was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease, and both recovered after rituximab infusion. Haplo-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73% after a median follow-up of 42 months, indicating its effectiveness as a salvage therapy. These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors.

Keywords： severe aplastic anemia non-severe acquired aplastic anemia haploidentical bone marrow transplantation

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Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 139-143 doi: 10.1007/s11684-019-0736-2

Abstract: The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was

Keywords： adult antibiotic viral pneumonia

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Diagnosis and management of acquired thrombotic thrombocytopenic purpura in southeast China: a single

Xinping Zhou,Xingnong Ye,Yanling Ren,Chen Mei,Liya Ma,Jiansong Huang,Weilai Xu,Juying Wei,Li Ye,Wenyuan Mai,Wenbin Qian,Haitao Meng,Jie Jin,Hongyan Tong

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 430-436 doi: 10.1007/s11684-016-0492-5

Abstract:

Acquired thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening thrombotic microangiopathyThis study aimed to provide a profile of the diagnosis and management of patients with acquired TTP collectedA total of 60 patients diagnosed with acute acquired TTP from March 2005 to August 2015 were enrolled

Keywords： thrombotic thrombocytopenic purpura ADAMTS 13 plasma exchange

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associatedgenes were used for drug resistance surveillance.This study indicated that the antifolate resistance levels of P. vivax parasites were differentacross China and molecular markers could be used to rapidly monitor drug resistance.

Keywords： drug resistance antifolates molecular markers Plasmodium vivax China

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Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1, Pages 4-4 doi: 10.1007/s11783-021-1438-y

Abstract: Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs).However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system

Keywords： Antibiotic resistance genes Metal resistance genes Metagenomic analysis Microplastics Mariculture

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Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 338-342 doi: 10.1007/s11684-007-0065-8

Abstract: not be explained by a single cause or factor and they are probably related to various congenital and acquired

Keywords： sarcoplasmic coagulation acquired ventricular myocardium sino-atrial autopsied

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: While most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistanceThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatinduce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired

Keywords： cancer drug resistance genetic screens senescence targeted therapy

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Transmission of antibiotic resistance genes in agroecosystems: an overview

Jizheng HE, Zhenzhen YAN, Qinglin CHEN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3, Pages 329-332 doi: 10.15302/J-FASE-2020333

Abstract: antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistanceThe spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens isThe future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems

Keywords： agroecosystem antibiotic resistance public health soil-plant system

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swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1342-x

Abstract:

• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.

Keywords： Pig manure Antibiotics Anaerobic digestion Resistance genes Microbial community

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Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1124-5

Abstract:

Extracellular DNA structure damaged by chlorination was characterized.

Integrity of extracellular ARG genetic information after chlorination was determined.

Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs.

Plasmid DNA/ARGs were less readily broken down than genomic DNA.

The Bioanalyzer methodology effectively documented damage incurred to DNA.

Keywords： Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract:

Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes

Keywords： branched-chain amino acids leucine isoleucine valine insulin resistance

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Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistancemetabolic intervention for tumor-infiltrating immunocytes could offer fresh opportunities to break the resistanceHerein, we elaborate potential mechanisms underlying immunotherapy resistance from a novel dimensionhope of offering a reference for targeting metabolic vulnerabilities to circumvent immunotherapeutic resistance

Keywords： immune cell immunometabolism metabolic reprogramming immunotherapy resistance tumor microenvironment

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Characteristics of two transferable aminoglycoside resistance plasmids in

Chengjun Pu, Xiaoyan Gong, Ying Sun

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1119-2

Abstract:

pRKZ3 is a non-conjugative IncQ plasmid, while pKANJ7 is a conjugative IncX plasmid.

The optimal mating time of pKANJ7 varied under different conditions.

Both of the two transferable ARPs had little impact on the growth of their hosts.

A relatively high level of fitness cost was observed for pKANJ7.

The fitness cost of ARPs depended on their hosts.

Keywords： Escherichia coli Characteristics Aminoglycoside resistance plasmids Transfer Persistence

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Title Author Date Type Operation

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired

Journal Article

bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired

Journal Article

Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Journal Article

Diagnosis and management of acquired thrombotic thrombocytopenic purpura in southeast China: a single

Xinping Zhou,Xingnong Ye,Yanling Ren,Chen Mei,Liya Ma,Jiansong Huang,Weilai Xu,Juying Wei,Li Ye,Wenyuan Mai,Wenbin Qian,Haitao Meng,Jie Jin,Hongyan Tong

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Journal Article

Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Transmission of antibiotic resistance genes in agroecosystems: an overview